Molecular Formula | C18H20N4O4 |
Molar Mass | 356.38 |
Storage Condition | -20℃ |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.806 ml | 14.03 ml | 28.06 ml |
5 mM | 0.561 ml | 2.806 ml | 5.612 ml |
10 mM | 0.281 ml | 1.403 ml | 2.806 ml |
5 mM | 0.056 ml | 0.281 ml | 0.561 ml |
biological activity | JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases Inhibitor, the IC50 values for JNK-1 and JNK-2 were 45 nM and 160 nM, respectively. JNK Inhibitor VIII (TCS JNK 6o) inhibited JNK-1, JNK-2 and JNK-3, corresponding to Ki values of 2 nM, 4 nM and 52 nM, respectively. |
Target | Value |
JNK1 (Cell-free assay) | 2 nM(Ki) 45 nM |
JNK2 (Cell-free assay) | 4 nM(Ki) 160 nM |
JNK3 (Cell-free assay) | 52 nM(Ki) |